Protein misfolding as a cause and/or consequence of ALS pathology is discussed.
Mutant C9ORF72, SOD1, TDP-43, FUS induce proteostasis dysfunction.
Dual role of the protein disulphide isomerase (PDI) family of chaperones in ALS.
Chaperones are potential therapeutics against misfolded proteins in the pathogenesis of ALS.