Natural killer cell and gamma delta T cell alterations in enthesitis related arthritis category of juvenile idiopathic arthritis
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- 作者：Priyanka Gaur ; Ramnath Misra ; Amita Aggarwal ; amita@sgpgi.ac.in" class="auth_mail" title="E-mail the corresponding author ; aa.amita@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Killer immunoglobulin-like receptors ; Innate immune cells ; Childhood arthritis ; Perforin ; Synovial fluid ; Inflammation
- 刊名：Clinical Immunology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：161
- 期：2
- 页码：163-169
- 全文大小：920 K
文摘
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In ERA PB, NK cells are increased but have less perforin and high KIR3DL expression.
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In SF CD56bright NK cells are predominant with low levels of perforin and KIR3DL.
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NK and γδ-T cells may contribute to the inflammation in ERA by producing IL-17.