Effects of HA and NA glycosylation pattern changes on the transmission of avian influenza A(H7N9) virus in guinea pigs
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- 作者：Sehee Park1 ; Ilseob Lee1 ; Jin Il Kim1 ; Joon-Yong Bae ; Kirim Yoo ; Juwon Kim ; Misun Nam ; Miso Park ; Soo-Hyeon Yun ; Woo In Cho ; Yeong-Su Kim ; Yun Young Ko ; Man-Seong Park ; manseong.park@gmail.com" class="auth_mail" title="E-mail the corresponding author ; ms0392@korea.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Influenza A(H7N9) virus ; Hemagglutinin ; Neuraminidase ; N-linked glycosylation ; Transmission
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：14 October 2016
- 年：2016
- 卷：479
- 期：2
- 页码：192-197
- 全文大小：1661 K
文摘
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Avian influenza H7N9 virus has posed a public health concern since 2013.
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HA and NA glycosylation may change viral characteristics including transmission.
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But, HA glycosylation changes decreased transmission efficiency.
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Only a functionally-balanced NA glycosylation could reserve viral transmission.
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Glycosylation change may confer benefit to a novel H7N9 strain of pandemic potential.