Development of a consumer product ingredient database for chemical exposure screening and prioritization

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• 作者：M.-R. Goldsmith ; C.M. Grulke ; R.D. Brooks ; T.R. Transue ; Y.M. Tan ; A. Frame ; P.P. Egeghy ; R. Edwards ; D.T. Chang ; R. Tornero-Velez ; K. Isaacs ; A. Wang ; J. Johnson ; K. Holm ; M. Reich ; J. Mitchell ; D.A. Vallero ; L. Phillips ; M. Phillips ; J.F. Wambaugh ; R.S. Judson ; et al.
• 关键词：ACToR ; Aggregated Computational Toxicology Resource ; ADME ; Absorption ; Distribution ; Metabolism ; and Elimination ; CAS-RN ; chemical abstracts service registry number ; CBI ; confidential business information ; CGI ; common gateway interface ; CHAD ; Consolidated Human Activity Database ; CPCPdb ; Consumer Product Chemical Profile Database ; CPSC ; Consumer Product Safety Commission ; CTCP ; Clinical Toxicology of Commercial Products ; DSSTox ; Distributed Structure-Searchable Toxicity Database ; EFH ; Exposure F
• 刊名：Food and Chemical Toxicology
• 出版年：March, 2014
• 年：2014
• 卷：65
• 期：Complete
• 页码：269-279
• 全文大小：1455 K

文摘

Consumer products are a primary source of chemical exposures, yet little structured information is available on the chemical ingredients of these products and the concentrations at which ingredients are present. To address this data gap, we created a database of chemicals in consumer products using product Material Safety Data Sheets (MSDSs) publicly provided by a large retailer. The resulting database represents 1797 unique chemicals mapped to 8921 consumer products and a hierarchy of 353 consumer product 鈥渦se categories鈥?within a total of 15 top-level categories. We examine the utility of this database and discuss ways in which it will support (i) exposure screening and prioritization, (ii) generic or framework formulations for several indoor/consumer product exposure modeling initiatives, (iii) candidate chemical selection for monitoring near field exposure from proximal sources, and (iv) as activity tracers or ubiquitous exposure sources using 鈥渃hemical space鈥?map analyses. Chemicals present at high concentrations and across multiple consumer products and use categories that hold high exposure potential are identified. Our database is publicly available to serve regulators, retailers, manufacturers, and the public for predictive screening of chemicals in new and existing consumer products on the basis of exposure and risk.