Lipid transfer and metabolism across the endolysosomal-mitochondrial boundary
详细信息 查看全文
- 作者：Tiziana Danielea ; b ; Maria Vittoria Schiaffinoc ; schiaffino.mariavittoria@hsr.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPK ; AMP-activated protein kinase ; ATG ; autophagy-related ; CL ; cardiolipin ; EM ; electron microscopy ; EMC ; ER membrane protein complex ; ER ; endoplasmic reticulum ; ERMES ; ER-mitochondria encounter structure ; FFAT ; two phenylalanines in an acid tract ; HOPS ; homotypic fusion and vacuole protein sorting ; LD ; lipid droplet ; LDL ; low-density lipoprotein ; LE ; late endosome ; LRO ; lysosome-related organelle ; LTP ; lipid transfer protein ; MAM ; mitochondria-associated membrane ; MCS ; membrane contact site ; M
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：1861
- 期：8
- 页码：880-894
- 全文大小：2214 K
文摘
- •
Lysosomes and mitochondria play critical roles in lipid metabolism and degradation.
- •
Lysosomes and mitochondria establish membrane contacts with each other and the ER.
- •
Autophagosomes and lipid droplets also establish membrane contacts with mitochondria.
- •
A dynamic and coordinated organelle network controls lipid metabolism and degradation.
- •
Interorganelle connections have relevant implications for biomedical research.