Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats
Oxidative stress in the hypothalamus is associated with hypertension. Oleuropein supplementation attenuated hypertension symptoms in SHR. Oleuropein inhibited PVN oxidative stress in SHR. Oleuropein attenuated PVN mitochondrial impairment in SHR. The effect of oleuropein on the PVN may occur via the activation of the Nrf2 pathway.