Lipopolysaccharide impairs hepatocyte ureagenesis from ammonia: Involvement of mitochondrial aquaporin-8
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- 作者：Leandro R. Soriaa ; Julieta Marronea ; Sara M. Molinasa ; Guillermo L. Lehmanna ; b ; Giuseppe Calamitac ; Raú ; l A. Marinellia ; rmarinel@unr.edu.ar" class="auth_mail ; marinelli@ifise-conicet.gov.ar" class="auth_mail
- 关键词：LPS ; lipopolysaccharide ; AQP ; aquaporin ; IMM ; inner mitochondrial membranes ; mtAQP8 ; mitochondrial aquaporin-8 ; CPS1 ; carbamyl phosphate synthetase 1 ; OTC ; ornithine transcarbamylase
- 刊名：FEBS Letters
- 出版年：2 May 2014
- 年：2014
- 卷：588
- 期：9
- 页码：1686-1691
- 全文大小：658 K
文摘
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Lipopolysaccharide down-regulates hepatocyte mitochondrial aquaporin-8 expression.
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Lipopolysaccharide decreases mitochondrial ammonia diffusional permeability.
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Lipopolysaccharide impairs hepatocyte ureagenesis from ammonia.
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A role for aquaporin-8 in defective hepatic ammonia removal in sepsis is suggested.