Rg1 prevents myocardial hypoxia/reoxygenation injury by regulating mitochondrial dynamics imbalance via modulation of glutamate dehydrogenase and mitofusin 2
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- 作者：Gengting Donga ; Tingbo Chena ; Xuecong Rena ; Zhifeng Zhanga ; Weixue Huangb ; Liang Liua ; Pei Luoa ; pluo@must.edu.mo" class="auth_mail" title="E-mail the corresponding author ; Hua Zhoua ; hzhou@must.edu.mo" class="auth_mail" title="E-mail the corresponding author
- 关键词：H/R ; hypoxia/reoxygenation ; I/R ; ischemia/reperfusion ; CK ; creatine kinase ; LDH ; lactate dehydrogenase ; ROS ; reactive oxygen species ; OCR ; oxygen consumption rate ; ECAR ; extracellular acidification rate ; α-KG ; α-ketoglutaric acid ; GDH ; glutamate dehydrogenase ; MFN2 ; mitofusin 2 ; MFN1 ; mitofusin 1 ; OPA1 ; optic atrophy 1 ; Drp1 ; dynamin-related protein 1 ; KRB ; Krebs&ndash ; Ringer Bicarbonate
- 刊名：Mitochondrion
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：26
- 期：Complete
- 页码：7-18
- 全文大小：2165 K
文摘
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We investigated a protective mechanism of Rg1 on an in vitro cardiomyocyte death induced by H/R.
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Rg1 moderated GDH dysregulation and protected against H/R-induced mitochondrial dysfunction.
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Rg1 up-regulated MFN2 leading to preventing imbalance of mitochondrial dynamics following H/R.