SIRT3, SIRT4 and SIRT5 modulate acyl modifications such as acetylation and succinylation.
Mitochondrial SIRTs are implicated in metabolism, mitochondrial fidelity, and cell stress.
Alterations in the expression/activity of SIRT3, SIRT4, SIRT5 are linked with disease.
Questions remain about the potential of mitochondrial SIRTs as therapeutic targets.