AGC1/2, the mitochondrial aspartate-glutamate carriers
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- 作者：N.D. Amoedoa ; b ; c ; 1 ; G. Punzia ; b ; d ; 1 ; E. Obrea ; b ; D. Lacombea ; b ; A. De Grassid ; C.L. Pierrid ; ciroleopierri@gmail.com" class="auth_mail" title="E-mail the corresponding author ; ciro.pierri@uniba.it" class="auth_mail" title="E-mail the corresponding author ; R. Rossignola ; b ; rossig@u-bordeaux2.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：AGC ; aspartate/glutamate carrier ; CNS ; central nervous system ; CTLN2 ; Type II citrullinemia ; G3P ; glycerol 3 phosphate ; GOT ; Glutamic-oxaloacetic transaminase ; LDH ; lactate dehydrogenase ; MAS ; malate aspartate shuttle ; MCF ; mitochondrial carrier family ; MCT ; monocarboxylate transporter ; Mü ; C ; Mü ; ller cells ; NiCCD ; Neonatal intrahepatic caused by citrin deficiency ; OAA ; oxaloacetate ; OMIM ; Online mendelian inheritance in man database ; OXPHOS ; Oxidative Phosphorlation ; PK ; pyruvate kinase
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：1863
- 期：10
- 页码：2394-2412
- 全文大小：3896 K
文摘
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AGC1 and AGC2 export aspartate from mitochondria in exchange for cytosolic glutamate and a proton.
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The kinetic properties of AGCs were extensively studied in proteoliposomes.
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AGCs participate to cellular REDOX homeostasis and the calcium-mediated control of mitochondrial respiration via the malate-aspartate shuttle.
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AGCs gene deficiencies are responsible for rare diseases.
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AGC1 is central to neuronal physiology and also plays a role in glutamate-induced excitotoxicity.
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AGCs are overexpressed in several types of human tumors.
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In silico and in vitro screenings of chemical libraries for identifying new AGC pharmacological modulators are in progress