Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease

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• 作者：TaeHun Kim^a ; ^b ; ¹ ; Ha Yun Yang^a ; ^d ; ¹ ; Beoung Gun Park^a ; Seo Yun Jung^a ; Jong-Hyun Park^a ; Ki Duk Park^a ; ^b ; Sun-Joon Min^c ; Jinsung Tae^d ; Hyejin Yang^e ; Suengmok Cho^e ; Sung Jin Cho^f ; Hyundong Song^g ; Inhee Mook-Jung^g ; Jiyoun Lee^h ; ^{jlee@sungshin.ac.kr} ; Ae Nim Pae^a ; ^b ; ^{anpae@kist.re.kr}
• 关键词：Translocator protein ; TSPO ; Mitochondrial permeability transition pore ; Alzheimer's disease ; Mitochondrial dysfunction ; Aβ
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：1172-1192
• 全文大小：2319 K
• 卷排序：125

文摘

Benzimidazole derivatives were synthesized as mitochondrial functional modulators. Mitochondrial functional assays were performed to assess their restoring ability. Lead compound 25 effectively improved cognitive function in AD animal models.