Altered mitochondrial quality control signaling in muscle of old gastric cancer patients with cachexia

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• 作者：Emanuele Marzetti^a ; Maria Lorenzi^a ; Francesco Landi^a ; Anna Picca^a ; Fausto Rosa^b ; Fabiana Tanganelli^a ; Marco Galli^a ; Giovanni Battista Doglietto^b ; Fabio Pacelli^b ; Matteo Cesari^c ; ^d ; Roberto Bernabei^a ; Riccardo Calvani^a ; ^{riccardo.calvani@gmail.com} ; Maurizio Bossola^b
• 关键词：Muscle wasting ; Mitochondrial dynamics ; Mitochondrial biogenesis ; Mitophagy ; Cachexia ; Bioenergetics
• 刊名：Experimental Gerontology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：87
• 期：part_PA
• 页码：92-99
• 全文大小：614 K
• 卷排序：87

文摘

Cachexia is accountable for multiple adverse outcomes in cancer patients. Muscle wasting is a major feature of aging and cancer cachexia. Mitochondrial dysfunction may be involved in sarcopenia and cancer cachexia. Mitochondrial quality control is altered in old patients with cancer cachexia. Mitochondrial fidelity pathways may be targeted for interventions against cachexia.