刊名:Biochimica et Biophysica Acta (BBA) - General Subjects
出版年:2017
出版时间:January 2017
年:2017
卷:1861
期:1
页码:2912-2921
全文大小:2175 K
卷排序:1861
文摘
NOX4 predominantly localizes in the mitochondria in the liver of mice, and chronic alcohol exposure increases hepatic NOX4. Inhibition of NOX4 activity decreases alcohol-elevated serum hydrogen peroxide levels. Inhibition of NOX4 activity decreases alcohol-induced fat accumulation but increases HNF-4α and CPT-1 in the liver. Inhibition of NOX4 activity decreases alcohol-induced mitochondrial apoptotic cell death pathway. Knockdown of NOX4 protects against ethanol-induced loss of mitochondrial membrane potential and generation of ROS.