Intramitochondrial phospholipid trafficking

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• 作者：Takashi Tatsuta^a ; ^{t.tatsuta@uni-koeln.de} ; Thomas Langer^a ; ^b ; ^{thomas.langer@uni-koeln.de}
• 关键词：CDP ; cytidine diphosphate ; DAG ; diacylglycerol ; CL ; cardiolipin ; PA ; phosphatidic acid ; PC ; phosphatidylcholine ; PE ; phosphatidylethanolamine ; PI ; phosphatidylinositol ; PS ; phosphatidylserine ; PG ; phosphatidylglycerol ; PGP ; phosphatidylglycerolphosphate ; MLCL ; monolysocardiolipin ; IM ; inner membrane ; IMS ; intermembrane space ; OM ; outer membrane ; ER ; endoplasmic reticulum ; MAM ; mitochondria associated membrane ; CS ; contact sites ; MICOS ; mitochondrial contact site and cristae organizing system ; AG
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1862
• 期：1
• 页码：81-89
• 全文大小：867 K
• 卷排序：1862

文摘

Functions of mitochondria depend on lipid transport between their membranes. Ups/PRELI proteins serve as lipid-specific intramitochondrial lipid transfer proteins. Phospholipid transfer occurs at membrane contact sites. Phosphatidylethanolamine can be synthesized in both mitochondrial membranes. Phospholipid composition determines the architecture of mitochondrial membranes.