Distinctive distribution of brain volume reductions in MELAS and mitochondrial DNA A3243G mutation carriers: A voxel-based morphometric study
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- 作者：Koyo Tsujikawaa ; b ; 1 ; Joe Sendaa ; c ; 1 ; Keizo Yasuib ; Yasuhiro Hasegawab ; d ; Minoru Hoshiyamae ; Masahisa Katsunoa ; Gen Sobuea ; f ; sobueg@med.nagoya-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：MELAS ; Mitochondrial DNA A3243G mutation carriers ; Voxel-based morphometry ; Superior parietal lobule ; Precuneus ; Middle temporal gyrus ; Posterior lobe
- 刊名：Mitochondrion
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：229-235
- 全文大小：1387 K
文摘
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We studied latent brain atrophy in MELAS and mitochondrial DNA A3243G mutation carriers using voxel-based morphometry.
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The grey matter volume reductions in A3243G carriers were less extensive than in the MELAS patients.
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Both MELAS patients and A3243G carriers shared a common spatial distribution of grey matter volume reductions.