No evidence of ischemia in stroke-like lesions of mitochondrial POLG encephalopathy

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• 作者：Charalampos Tzoulis ; MD ; PhD^a ; ^b ; ¹ ; Eilen Henriksen ; MSc^b ; ¹ ; Hrvoje Miletic ; MD ; PhD^c ; ^d ; Laurence A. Bindoff ; MD ; PhD^a ; ^b ; ^{laurence.bindoff@nevro.uib.no}
• 关键词：COX ; cytochrome oxidase ; FFPE ; formalin-fixed paraffin embedded ; GFAP ; glial fibrillary acidic protein ; HE ; hematoxylin & eosin ; MRI ; magnetic resonance imaging ; MSCAE ; mitochondrial spinocerebellar ataxia and epilepsy ; MtDNA ; mitochondrial DNA ; POLG ; polymerase gamma ; SLE ; stroke-like episode ; BBB ; Blood brain barrier
• 刊名：Mitochondrion
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：32
• 期：Complete
• 页码：10-15
• 全文大小：1998 K
• 卷排序：32

文摘

Vascularity is increased in acute and chronic brain lesions caused by POLG mutations. Stroke-like lesions of POLG encephalopathy do not show an ischemic etiology. Mitochondrial failure triggers neovascularization in POLG encephalopathy.