Effects of amphetamines on mitochondrial function: role of free radicals and oxidative stress

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• 作者：Brown ; Jeffrey M. ; Yamamoto ; Bryan K.
• 关键词：Amphetamine ; Mitochondria ; Free radicals ; Oxidative stress ; Reactive oxygen species ; Reactive nitrogen species ; ETC ; electron transport chain ; NO ; nitric oxide ; NOS ; nitric oxide synthase ; ONOO^&minus ; ; peroxynitrite ; PTP ; permeability transitio
• 刊名：Pharmacology and Therapeutics
• 出版年：2003
• 出版时间：July, 2003
• 年：2003
• 卷：99
• 期：1
• 页码：45-53
• 全文大小：321 K

文摘

Amphetamine-like psychostimulants are associated with long-term decreases in markers for monoaminergic neurons, suggesting neuronal loss and/or damage within the brain. This long-term “toxicity” results from formation of free radicals, particularly reactive oxygen species (ROS) and reactive nitrogen species (RNS), although the mechanism(s) of ROS and RNS formation are unclear.