Activation and Degradation of Mitofusins: Two Pathways Regulate Mitochondrial Fusion by Reversible Ubiquitylation

详细信息    查看全文

• 作者：Nils Wiedemann¹ ; ² ; Sebastian B. Stiller¹ ; ³ ; Nikolaus Pfanner¹ ; ² ; ^{nikolaus.pfanner@biochemie.uni-freiburg.de}
• 刊名：Molecular Cell
• 出版年：2013
• 出版时间：7 February, 2013
• 年：2013
• 卷：49
• 期：3
• 页码：423-425
• 全文大小：231 K

文摘

Mitofusins are large GTPases essential for mitochondrial fusion. In this issue, report that two independent pathways of ubiquitylation/deubiquitylation control activation and degradation of mitofusins, revealing a sophisticated mechanism of regulating mitochondrial dynamics.