Direct hyperplasia does not enhance the kinetics of liver repopulation in a new model of hepatocyte transplantation in the rat
详细信息 查看全文
- 作者：Pani ; Paolo ; Laconi ; Sergio ; Pillai ; Sara ; Scintu ; Franca ; Curreli ; Francesca ; Shafritz ; David A. ; et. al.
- 关键词：Hepatocyte transplantation ; Liver repopulation ; Mitogen ; Mitoinhibition ; Pyrrolizidine alkaloids ; Retrorsine
- 刊名：Journal of Hepatology
- 出版年：1999
- 出版时间：August, 1999
- 年：1999
- 卷：31
- 期：2
- 页码：354-359
- 全文大小：762 K
文摘
Background/Aims: We have recently developed a new model of extensive liver repopulation by transplanted hepatocytes following exposure to pyrrolizidine alkaloids. In the present study, the effect of 2/3 partial hepatectomy (PH) and that of a potent direct liver mitogen, lead nitrate, were compared in their ability to modulate the kinetics of liver repopulation.