Prognostic value of 2-[¹⁸ F]fluoro-2-deoxy-D-glucose positron emission tomography for patients with oral squamous cell carcinoma treated with retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy

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• 作者：Mai Shimizu ; DDS^a ; Kenji Mitsudo ; DDS ; PhD^a ; ^{mitsudo@yokohama-cu.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Izumi Koike ; MD ; PhD^b ; Masataka Taguri ; PhD^c ; Toshinori Iwai ; DDS^a ; Toshiyuki Koizumi ; DDS ; PhD^a ; Senri Oguri ; DDS ; PhD^a ; Mitomu Kioi ; DDS ; PhD^a ; Makoto Hirota ; DDS ; PhD^a ; Tomio Inoue ; MD ; PhD^b ; Iwai Tohnai ; DDS ; PhD^a
• 刊名：Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：121
• 期：3
• 页码：239-247
• 全文大小：491 K

文摘

To investigate whether 2-[¹⁸ F]fluoro-2-deoxy-D-glucose (FDG) uptake of primary tumor in oral squamous cell carcinoma (OSCC) could predict prognosis.

Study Design

Sixty-nine patients with OSCC who underwent retrograde superselective intra-arterial chemoradiotherapy were recruited and underwent dual-time-point FDG positron emission tomography twice, before treatment and 4 weeks after treatment. FDG uptake was defined as the standardized uptake value (SUVmax). The retention index (RI) and the percent change in SUV (% change SUV), derived from the dual-time-point scan, were calculated.

Results

On univariate analysis, patients with high pre-SUV, RI, and percent change SUV values had significantly worse overall survival and disease-free survival compared with patients with low values. On multivariate analysis, high pre-RI (≥20.6%) and high percent change SUV (≥60.0%) (delayed-image) were associated with significantly worse overall survival. High pre-SUV (≥9.6) (delayed-image) and high pre-RI (≥20.6%) were associated with significantly shorter disease-free survival.

Conclusions

Dual-time-point FDG positron emission tomography in OSCC provided prognostic information and predicted patient outcome.