Total synthesis of (3R,5R) and (3R,5S)-sonnerlactones
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- 作者：Chakrapani Sanaboinaa ; b ; Sridhar Chidarab ; Samaresh Janac ; samareshfch@kiit.ac.in" class="auth_mail" title="E-mail the corresponding author ; samarpdp@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Laxminarayana Eppakayalad
- 关键词：Sonnerlactone ; Total synthesis ; Enantioselective ; Mitsunobu inversion ; Ring-closing metathesis
- 刊名：Tetrahedron Letters
- 出版年：2016
- 出版时间：20 April 2016
- 年：2016
- 卷：57
- 期：16
- 页码：1767-1770
- 全文大小：656 K
文摘
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(3R,5R) and (3R,5S)-sonnerlactone: isolated from the marine derived fungus Zh6-B1.
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These compounds inhibit the growth of KV/MDR cell line up to certain extent.
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These lactones exhibit antibacterial, antifungal and anticancer activities.
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Structural features and important medicinal activity, increased the importance to make these.
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Mitsunobu reaction and RCM protocol have been applied to construct the core.