Chocolate intake and incidence of heart failure: Findings from the Cohort of Swedish Men

详细信息    查看全文

• 作者：Daniel A. Steinhaus ; MD^a ; Elizabeth Mostofsky ; ScD^b ; ^c ; Emily B. Levitan ; ScD^d ; Kirsten S. Dorans ; BSc^b ; ^c ; Niclas Hå ; kansson ; PhD^e ; Alicja Wolk ; DrMedSci^e ; Murray A. Mittleman ; MD ; DrPH^b ; ^c ; ^{mmittlem@bidmc.harvard.edu}
• 刊名：American Heart Journal
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：183
• 期：Complete
• 页码：18-23
• 全文大小：205 K
• 卷排序：183

文摘

The objective of this study was to evaluate the association of chocolate consumption and heart failure (HF) in a large population of Swedish men.MethodsWe conducted a prospective cohort study of 31,917 men 45-79 years old with no history of myocardial infarction, diabetes, or HF at baseline who were participants in the population-based Cohort of Swedish Men study. Chocolate consumption was assessed through a self-administrated food frequency questionnaire. Participants were followed for HF hospitalization or mortality from January 1, 1998, to December 31, 2011, using record linkage to the Swedish inpatient and cause-of-death registries.ResultsDuring 14 years of follow-up, 2,157 men were hospitalized (n = 1,901) or died from incident HF (n = 256). Compared with subjects who reported no chocolate intake, the multivariable-adjusted rate ratio of HF was 0.88 (95% CI 0.78-0.99) for those consuming 1-3 servings per month, 0.83 (95% CI 0.72-0.94) for those consuming 1-2 servings per week, 0.82 (95% CI 0.68-0.99) for those consuming 3-6 servings per week, and 1.10 (95% CI 0.84-1.45) for those consuming ≥1 serving per day (P for quadratic trend = .001).ConclusionsIn this large prospective cohort study, there was a J-shaped relationship between chocolate consumption and HF incidence. Moderate chocolate consumption was associated with a lower rate of HF hospitalization or death, but the protective association was not observed among individuals consuming ≥1 serving per day.Journal Subject Codes: Etiology: Epidemiology, Heart failure: Congestive