Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections
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- 作者：Mark J. Mitton-Fry ; Joel T. Arcari ; Matthew F. Brown ; Jeffrey M. Casavant ; Steven M. Finegan ; Mark E. Flanagan ; Hongying Gao ; David M. George ; Brian S. Gerstenberger ; Seungil Han ; Joel R. Hardink ; Thomas M. Harris ; Thuy Hoang ; Michael D. Hub ; Rebecca Irvine ; Manjinder S. Lall ; M. Megan Lemmon ; Chao Li ; Jian Lin ; S ; ra P. McCurdy ; et al.
- 关键词：Monobactam ; Gram-negative ; Pseudomonas aeruginosa ; Klebsiella pneumoniae ; Escherichia coli ; Siderophore ; MC-1
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2012
- 出版时间：15 September, 2012
- 年：2012
- 卷：22
- 期：18
- 页码：5989-5994
- 全文大小：784 K
文摘
Novel siderophore-linked monobactams with in vitro and in vivo anti-microbial activity against MDR Gram-negative pathogens are described.