Acute effect of the anti-addiction drug bupropion on extracellular dopamine concentrations in the human striatum: An [¹¹C]raclopride PET study

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• 作者：Alice Egerton ; John P. Shotbolt ; Paul R.A. Stokes ; Ella Hirani ; Rabia Ahmad ; Julia M. Lappin ; Suzanne J. Reeves ; Mitul A. Mehta ; Oliver D. Howes ; Paul M. Grasby
• 关键词：Bupropion ; Dopamine ; Imaging positron emission tomography ; [¹¹C]raclopride ; Striatum ; Addiction ; Depression ; Mechanism ; Smoking ; Rat ; Human
• 刊名：NeuroImage
• 出版年：2010
• 出版时间：March 2010
• 年：2010
• 卷：50
• 期：1
• 页码：260-266
• 全文大小：1605 K

文摘

Bupropion is an effective medication in treating addiction and is widely used as an aid to smoking cessation. Bupropion inhibits striatal dopamine reuptake via dopamine transporter blockade, but it is unknown whether this leads to increased extracellular dopamine levels at clinical doses in man. The effects of bupropion on extracellular dopamine levels in the striatum were investigated using [¹¹C]raclopride positron emission tomography (PET) imaging in rats administered saline, 11 or 25 mg/kg bupropion i.p. and in healthy human volunteers administered either placebo or 150 mg bupropion (Zyban® Sustained-Release). A cognitive task was used to stimulate dopamine release in the human study. In rats, bupropion significantly decreased [¹¹C]raclopride specific binding in the striatum, consistent with increases in extracellular dopamine concentrations. In man, no significant decreases in striatal [¹¹C]raclopride specific binding were observed. Levels of dopamine transporter occupancy in the rat at 11 and 25 mg/kg bupropion i.p. were higher than predicted to occur in man at the dose used. Thus, these data indicate that, at the low levels of dopamine transporter occupancy achieved in man at clinical doses, bupropion does not increase extracellular dopamine levels. These findings have important implications for understanding the mechanism of action underlying bupropions' therapeutic efficacy and for the development of novel treatments for addiction and depression.