Risk Stratification of 7,732 Hepatectomy Cases in 2011 from the National Clinical Database for Japan

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• 作者：Akira Kenjo ; MD ; PhD^a ; ^d ; Hiroaki Miyata ; PhD^a ; ^c ; ^e ; Mitsukazu Gotoh ; MD ; PhD^a ; ^d ; ^{mgotoh@fmu.ac.jp" class="auth_mail} ; Yukou Kitagawa ; MD ; PhD ; FACS^a ; ^f ; Mitsuo Shimada ; MD ; PhD ; FACS^a ; ^g ; Hideo Baba ; MD ; PhD ; FACS^a ; ^h ; Naohiro Tomita ; MD ; PhD^a ; ⁱ ; Wataru Kimura ; MD ; PhD^a ; ^j ; Kenichi Sugihara ; MD ; PhD^b ; ^k ; Masaki Mori ; MD ; PhD ; FACS^b ; ^l
• 关键词：ADL ; activities of daily living ; ASA ; American Society of Anesthesiologists ; JSGS ; Japan Society of Gastroenterological Surgery ; LOS ; length of stay ; MOS ; more than 1 segment ; NCD ; National Clinical Database ; PT-INR ; prothrombin time-international normalized ratio ; ROC ; receiver operating characteristic ; SSI ; surgical site infection
• 刊名：Journal of the American College of Surgeons
• 出版年：March, 2014
• 年：2014
• 卷：218
• 期：3
• 页码：412-422
• 全文大小：540 K

文摘

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Background

There has been no report on risk stratification for hepatectomy using a nationwide surgical database in Japan. The objective of this study was to evaluate mortality and variables associated with surgical outcomes of hepatectomy at a national level.

Study Design

We analyzed records of 7,732 patients who underwent hepatectomy for more than 1 segment (MOS) during 2011 in 987 different hospitals, as identified in the National Clinical Database (NCD) of Japan. The NCD captured 30-day morbidity and mortality as well as 90-day in-hospital mortality outcomes, which were submitted through a web-based data entry system. Based on 80% of the population, independent predictors for 30-day mortality and 90-day in-hospital mortality were calculated using a logistic regression model. The risk factors were validated with the remaining 20% of the cohort.

Results

The median postoperative length of hospitalization was 16.0 days. The overall patient morbidity rate was 32.1%. Thirty-day mortality and 90-day in-hospital mortality rates were 2.0% and 4.0%, respectively. Totals of 14 and 23 risk factors were respectively identified for 30-day mortality and 90-day in-hospital mortality. Factors associated with risk for 90-day in-hospital mortality were preoperative condition and comorbidity, operative indication (emergency surgery, intrahepatic/perihilar cholangiocarcinoma, or gallbladder cancer), preoperative laboratory data, and extent and location of resected segments (segment 1, 7, or 8). As a performance metric, c-indices of 30-day mortality and 90-day in-hospital mortality were 0.714 and 0.761, respectively.

Conclusions

Here we report the first risk stratification analysis of hepatectomy using a Japanese nationwide surgical database. This system would predict surgical outcomes of hepatectomy and be useful to evaluate and benchmark performance.