Synthesis of azido derivatives of semotiadil, a novel 1,4-benzothiazine calcium antagonist, for photoaffinity probes of calcium channels

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• 作者：Watanabe ; Yoshifumi ; Osanai ; Ken ; Nishi ; Tatsuya ; Miyawaki ; Nobuaki ; Shii ; Daisuke ; Honda ; Toshio ; et. al.
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：1996
• 出版时间：August 20, 1996
• 年：1996
• 卷：6
• 期：16
• 页码：1923-1926
• 全文大小：192 K

文摘

Aliphatic and aromatic azido derivatives of semotiadil (1), a novel calcium antagonist with a 1,4-benzothiazine skeleton, were synthesized for developing photoaffinity probes of L type calcium channels. The azidophenoxy derivative 12 proved to be a potent calcium antagonist and its [³H]-labeled compound 16 would be a useful tool to clarify the binding sites of 1 to the calcium channels.