Oral midazolam for sedation in minor oral operations in children: A retrospective study

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• 作者：Atsushi Kohjitani ; Hitoshi Higuchi ; Masahiko Shimada ; Takuya Miyawaki
• 关键词：Oral sedation ; Children ; Midazolam ; Nitrous oxide ; Outpatient
• 刊名：British Journal of Oral and Maxillofacial Surgery
• 出版年：2008
• 出版时间：June 2008
• 年：2008
• 卷：46
• 期：4
• 页码：330-331
• 全文大小：123 K

文摘

Our aim was to find out the optimal dose of oral midazolam to sedate children according to age. Thirty-five patients aged 10 or under who had minor oral operations under sedation with midazolam were enrolled. Correlations between age (X) and dose of midazolam (mg/kg; Y) were analysed by Pearson's correlation coefficient, and relations were fitted by simple regression. Doses of midazolam were significantly reduced as age increased (Y = 0.969 − 0.04X; R = 0.48) in the satisfactory group (n = 25), whereas those in the overdose group (n = 10) (patients who vomited, became agitated, or took some time to come round) were significantly higher, decreased with age, and showed a better correlation coefficient (Y = 1.375 − 0.65X; R = 0.78). These findings suggest that both the requirement and threshold of midazolam decreases with age.