Growth of xenotransplanted leukemia cells is influenced by diet nutrients and is attenuated with 2-deoxyglucose
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- 作者：Norikazu Tsunekawa-Imai ; Hiroshi Miwa ; Masato Shikami ; Kazuto Suganuma ; Mineaki Goto ; Shohei Mizuno ; Miyuki Takahashi ; Motonori Mizutani ; Tomohiro Horio ; Hiroko Komatsubara ; Mayuko Gotou ; Hidesuke Yamamoto ; Motohiro Wakabayashi ; Masaya Watarai ; Ichiro Hanamura ; Akira Imamura ; Hidetsugu Mihara ; Masakazu Nitta
- 关键词：AML ; Xenotransplantation ; High fat diet ; Carbohydrate-dominant diet ; 2-Deoxyglucose (2-DG) ; Etomoxir
- 刊名：Leukemia Research
- 出版年：2013
- 出版时间：September, 2013
- 年：2013
- 卷：37
- 期：9
- 页码：1132-1136
- 全文大小：1834 K
文摘
We examined the effects of diet nutrients on xenotransplanted leukemia cells, THP-1 or NB4. THP-1 tumors showed more growth when fed with high fat diet, while NB4 tumors grew more with high carbohydrate diet. Then, administration of 2-deoxyglucose (a glycolysis inhibitor) showed a significant antitumor effect on both tumors: NB4 tumor showed large necrotic areas, while THP-1 tumor did not, but had augmented expression of enzymes for fatty acid oxidation. 2-Deoxyglucose inhibited the growth of NB4 by cell death because main energy producing pathway (glycolysis) was abolished, while 2-deoxyglucose slowed the growth of THP-1 by shifting energy metabolism to fatty acid ¦Â-oxidation.