Xenin delays gastric emptying rate and activates the brainstem in mice

详细信息    查看全文

• 作者：Eun Ran Kim ; Tooru M. Mizuno
• 关键词：Gut hormone ; Obesity ; Feeding ; Gastric emptying ; Brainstem
• 刊名：Neuroscience Letters
• 出版年：2010
• 出版时间：30 August 2010
• 年：2010
• 卷：481
• 期：1
• 页码：59-63
• 全文大小：221 K

文摘

Xenin, a 25-amino acid gastrointestinal peptide, inhibits feeding by acting through the central nervous system. Gastrointestinal hormones reduce food intake partly by activating the brainstem and inhibiting gastric emptying. Therefore, we hypothesized that xenin delays gastric emptying through the activation of the brainstem cells. To address this hypothesis, we examined the effect of intraperitoneal (i.p.) injection of xenin on gastric emptying rate and brainstem Fos expression in mice. Gastric emptying rate was reduced by about 93 % in xenin-treated mice compared to saline-treated control mice. The i.p. xenin injection significantly increased Fos-immunoreactive cells in the nucleus of the solitary tract (NTS) of the brainstem, but not area postrema (AP) and dorsal motor nucleus of the vagus (DMV). These findings support the hypothesis that xenin-induced anorexia is at least partly due to delayed gastric emptying and the activation of the NTS cells.