Activation of the MKL1/actin signaling pathway induces hormonal escape in estrogen-responsive breast cancer cell lines
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- 作者：Gwenneg Kerdivel ; Antoine Boudot ; Denis Habauzit ; Frederic Percevault ; Florence Demay ; Farzad Pakdel ; Gilles Flouriot ; gilles.flouriot@univ-rennes1.fr" class="auth_mail
- 关键词：MKL1 ; Hormone resistance ; Breast cancer ; Cell growth ; Estrogen receptor ; Tamoxifen
- 刊名：Molecular and Cellular Endocrinology
- 出版年：5 June 2014
- 年：2014
- 卷：390
- 期：1-2
- 页码：34-44
- 全文大小：2111 K
文摘
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MKL1 activity is enhanced in estrogen (E2)-independent breast cancer cell lines.
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MKL1 activation in E2-dependent MCF-7 cells represses estrogen receptor expression.
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MKL1 activation abolishes E2-dependent proliferation and transcription.
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Growth factor signaling and E2-independent proliferation are enhanced by MKL1.
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MKL1 activation result in hormonal escape and tamoxifen-resistance.