Harnessing the Hidden Antitumor Power of the MLL-AF4 Oncogene to Fight Leukemia

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• 作者：Smita Matkar¹ ; Bryson W. Katona¹ ; Xianxin Hua¹ ; ^{huax@mail.med.upenn.edu" class="auth_mail}
• 刊名：Cancer Cell
• 出版年：14 April, 2014
• 年：2014
• 卷：25
• 期：4
• 页码：411-413
• 全文大小：300 K

文摘

It is unclear whether the antiproliferative/proapoptotic activity of oncogenes can be pharmacologically reactivated in cancer cells. In this issue of Cancer Cell, Liu and colleagues report that a proteasome inhibitor reactivates an MLL-AF4 controlled antitumor program to kill leukemia cells in an oncogene dose- and cell type-dependent manner.