MECP2 Is Post-transcriptionally Regulated during Human Neurodevelopment by Combinatorial Action of RNA-Binding Proteins and miRNAs
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- 作者：Deivid C. Rodrigues1 ; Dae-Sung Kim1 ; 5 ; Guang Yang2 ; Kirill Zaslavsky1 ; 3 ; Kevin C.H. Ha3 ; 4 ; Rebecca S.F. Mok1 ; 3 ; P. Joel Ross1 ; 6 ; Melody Zhao1 ; 3 ; Alina Piekna1 ; Wei Wei1 ; Benjamin J. Blencowe3 ; 4 ; Quaid Morris3 ; 4 ; James Ellis1 ; 3 ; 7 ; jellis@sickkids.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：MECP2 ; post-transcriptional regulation ; Rett syndrome ; RNA-binding proteins ; miRNAs ; TIA1 ; HuC ; PUM1 ; mRNA stability ; translational regulation
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：11 October 2016
- 年：2016
- 卷：17
- 期：3
- 页码：720-734
- 全文大小：3926 K
文摘
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hESC model to study neurodevelopmental regulation of MECP2 3′ UTR use and function
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MECP2 long 3′ UTR transcript is destabilized by PUM1 and miRNAs in hESCs
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MECP2 translation is repressed by TIA1 in hESCs and enhanced by HuC in neurons
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Combinatorial circuitry regulates MECP2 3′ UTR stability and MECP2 protein levels