Endogenous NO induces NADPH and reduces nucleotide biosynthesis in HepG2 cells.
Trx1 and Grx1 have a pro-oxidant action on key proteins under nitrosative conditions.
Trx1 and Grx1 hamper the antiproliferative action of NO in tumoral cells.
Weakening of thiolic antioxidant defenses could help in the design of anti-tumoral therapies.