Novel phenylenediamine bridged mixed ligands dimetallic square planner Pt(II) complex inhibits MMPs expression via p53 and caspase-dependent signaling and suppress cancer metastasis and invasion

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• 作者：Faiz-Ur Rahman^a ; ¹ ; Amjad Ali^b ; ^c ; ¹ ; Inam Ullah Khan^d ; Hong-Quan Duong^e ; Rong Guo^a ; Hui Wang^a ; ^{wanghui@fudan.edu.cn} ; Zhan-Ting Li^a ; Dan-Wei Zhang^a ; ^{zhangdw@fudan.edu.cn}
• 关键词：Dimetallic Pt(II) complex ; Anticancer Pt(II) complex ; Cytotoxicity ; E. coli growth inhibition ; DNA interaction
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：1064-1075
• 全文大小：3098 K
• 卷排序：125

文摘

Synthesis of novel dimetallic Pt(II) complex. In vitro anticancer activity of Pt(II) complex. p53 and p53-dependent genes expression induced by dimetallic Pt(II) complex. caspase signaling, cell invasion and migration study. In vivo E. Coli Growth inhibition by Pt(II) complex.