Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice
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- 作者：Chao Genga ; Yinliang Zhanga ; Yong Gaoa ; Wufan Taob ; Huabing Zhangc ; Xiaojun Liua ; xiaojunliu@ibms.pumc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Fude Fanga ; fangfd@vip.sina.com" class="auth_mail" title="E-mail the corresponding author ; Yongsheng Changa ; changy@ibms.pumc.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mst1 ; Sirt1 ; Non-alcoholic fatty liver disease ; Oxidant stress
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：18 March 2016
- 年：2016
- 卷：471
- 期：4
- 页码：444-449
- 全文大小：1103 K
文摘
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Fasting and high-fat diet aggravate liver metabolic damage in Mst1−/− mice.
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Mst1 decreases Srebp-1c expression and increases antioxidant genes expression.
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Fasting-induced hepatic Sirt1 increase is attenuated in Mst1−/− mice.
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Mst1 increases the expression of Sirt1 by inhibiting Sirt1 ubiquitination.