Tungsten-induced carcinogenesis in human bronchial epithelial cells
详细信息 查看全文
- 作者：Freda Laulichta ; Jason Brocatoa ; Laura Cartularoa ; Joshua Vaughana ; Feng Wua ; Thomas Kluza ; Hong Suna ; Betul Akgol Oksuzb ; Steven Shenc ; Massimiliano Peanad ; Serenella Medicid ; Maria Antonietta Zoroddud ; Max Costaa ; Max.Costa@nyumc.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tungsten ; Cancer ; Beas-2B ; RNA-Seq ; In vitro ; Nude mice
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2015
- 出版时间：1 October 2015
- 年：2015
- 卷：288
- 期：1
- 页码：33-39
- 全文大小：946 K
文摘
- •
Tungsten (W) induces cell transformation and increases migration in vitro.
- •
W increases xenograft growth in nude mice.
- •
W altered the expression of cancer-related genes such as those involved in leukemia.
- •
Some of the dysregulated leukemia genes include, CD74, CTGF, MST4, and HOXB5.
- •
For the first time, data is presented that demonstrates tungsten's carcinogenic potential.