H-ras Inhibits the Hippo Pathway by Promoting Mst1/Mst2 Heterodimerization
详细信息 查看全文
- 作者：Sonali J. Rawat1 ; 2 ; 5 ; Daniela Araiza-Olivera1 ; 5 ; Luis E. Arias-Romero1 ; 3 ; Olga Villamar-Cruz1 ; 3 ; Tatiana Y. Prudnikova1 ; Heinrich Roder1 ; 4 ; Jonathan Chernoff1 ; j_chernoff@fccc.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Biology
- 出版年：2016
- 出版时间：20 June 2016
- 年：2016
- 卷：26
- 期：12
- 页码：1556-1563
- 全文大小：2148 K
文摘
- •
Mst1 and Mst2 form heterodimers in cells
- •
Mst1/Mst2 heterodimers have low kinase activity compared to homodimers
- •
Mst1/Mst2 heterodimerization is promoted by H-ras via an Erk-dependent mechanism
- •
Mst1−/− cells, which cannot form Mst1/Mst2 heterodimers, resist transformation by H-ras