Genetic risk score based on the prevalence of vertebral fracture in Japanese women with osteoporosis

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• 作者：Heying Zhou^a ; Seijiro Mori^a ; ^{mori_seijiro@tmghig.jp} ; Tatsuro Ishizaki^b ; Atsushi Takahashi^c ; ^d ; Koichi Matsuda^e ; Yukihiro Koretsune^f ; Shiro Minami^g ; Masahiko Higashiyama^h ; Shinji Imaiⁱ ; Kozo Yoshimori^j ; Minoru Doita^k ; Akira Yamada^l ; Satoshi Nagayama^m ; Kazuo Kanekoⁿ ; Satoshi Asai^o ; Masaki Shiono^p ; Michiaki Kubo^q ; Hideki Ito^r
• 关键词：GRS ; genetic risk score ; SNP ; single-nucleotide polymorphism ; PKDCC ; protein kinase domain containing ; cytoplasmic ; CDKAL1 ; CDK5-regulatory subunit-associated protein 1-like 1 ; WNT16 ; wingless-type MMTV-integration site family member 16 ; GPATCH1 ; G-patch domain-containing gene 1 ; CI ; confidence interval ; BMD ; bone mineral density ; GWAS ; genome-wide association studies ; OR ; odds ratio ; AUC ; area under the curve ; ROC ; receiver-operating characteristics
• 刊名：Bone Reports
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：5
• 期：Complete
• 页码：168-172
• 全文大小：293 K
• 卷排序：5

文摘

A genetic risk score to predict fracture risk based on vertebral fracture prevalence is proposed. Four single-nucleotide polymorphisms showed significant association with fracture. This method helps identify at-risk individuals and promotes preventive measures for fractures.