Nerve growth factor (NGF)-mediated regulation of p75NTR expression contributes to chemotherapeutic resistance in triple negative breast cancer cells
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- 作者：Reka Chakravarthy ; Katarzyna Mnich ; Adrienne M. Gorman ; Adrienne.gorman@nuigalway.ie" class="auth_mail" title="E-mail the corresponding author
- 关键词：Apoptosis ; Breast cancer cells ; Nerve growth factor (NGF) ; p75 neurotrophin receptor (p75NTR)
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：30 September 2016
- 年：2016
- 卷：478
- 期：4
- 页码：1541-1547
- 全文大小：1070 K
文摘
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NGF upregulates expression of p75NTR in triple negative breast cancer (TNBC) cells.
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Increased transcription and reduced proteolytic processing of p75NTR both contribute to NGF-mediated increase in p75NTR.
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The increase in p75NTR by NGF contributes to the resistance of TNBC to chemotherapy induced cell death.
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Patient samples show a positive correlation between NGF and NGFR levels in basal-like, ER positive and ER negative BC.