Recombinant human soluble thrombomodulin ameliorates cerebral ischemic injury through a high-mobility group box 1 inhibitory mechanism without hemorrhagic complications in mice
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- 作者：Yoshihiko Nakamuraa ; pdmxy827@yahoo.co.jp" class="auth_mail" title="E-mail the corresponding author ; Takafumi Nakanob ; c ; naka0625@fukuoka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Keiichi Irieb ; kirie@cis.fukuoka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kazunori Sanob ; ksano@fukuoka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Junichi Tanakaa ; junichi0927@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Yuta Yamashitab ; pd141002@cis.fukuoka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Tomomitsu Sathob ; satho@fukuoka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Koichi Matsuod ; ko1matsuo@fukuoka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Masayuki Fujiokab ; e ; mfujioka_2000_99@yahoo.co.jp" class="auth_mail" title="E-mail the corresponding author ; Hiroyasu Ishikuraa ; ishikurah@fukuoka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kenichi Mishimab ; e ; kenichi@fukuoka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Thrombomodulin ; High-mobility group box 1(HMGB1) ; Cerebral ischemia ; Stroke
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：362
- 期：Complete
- 页码：278-282
- 全文大小：482 K
文摘
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rhsTM significantly decreased plasma level of HMGB1 after cerebral ischemia.
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rhsTM significantly reduced the infarct volume and neurological impairment after cerebral ischemia.
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rhsTM improved ischemic stroke without hemorrhagic complications.