Experimental strategies towards increasing intracellular mitochondrial activity in oocytes: A systematic review

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• 作者：Sara Darbandi^a ; ^{saradarbandi@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Mahsa Darbandi^a ; ¹ ; ^{mahsadarbandi@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Hamid Reza Khorram khorshid^b ; ^{hrkk1@uswr.ac.ir" class="auth_mail" title="E-mail the corresponding author} ; Mohammad Reza Sadeghi^a ; ^{Sadeghi@Avicenna.ac.ir" class="auth_mail" title="E-mail the corresponding author} ; Safaa Al-Hasani^c ; ^{sf_alhasani@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ashok Agarwal^d ; ^{AGARWAA@ccf.org" class="auth_mail" title="E-mail the corresponding author} ; Abolfazl Shirazi^a ; ^{shiraziabbas@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Mahnaz Heidari^a ; ^{M.@avicenna.ar.ir" class="auth_mail" title="E-mail the corresponding author} ; Mohammad Mehdi Akhondi^a ; ^{Akhondi@Avicenna.ac.ir" class="auth_mail" title="E-mail the corresponding author} ; ^{M_Akhondi@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：mtDNA ; mitochondrial DNA ; MMP ; mitochondrial membrane potential ; TFAM ; mitochondrial transcription factor A ; FDA ; Food and Drug Administration ; MRT ; mitochondrial replacement therapy ; GV ; germinal vesicle ; M II ; metaphase II ; nDNA ; nuclear DNA ; PCR ; polymerase chain reaction ; AAV ; adenovirus-associated virus ; HMG ; high mobility group ; SCNT ; somatic cell nuclear transfer ; ER ; endoplasmic reticulum ; PMSG ; pregnant mare's serum gonadotropin ; ROS ; Reactive Oxygen Species ; CoQ10 ; coenzyme Q10
• 刊名：Mitochondrion
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：30
• 期：Complete
• 页码：8-17
• 全文大小：672 K

文摘

The mitochondrial complement is critical in sustaining the earliest stages of life. To improve the Assisted Reproductive Technology (ART), current methods of interest were evaluated for increasing the activity and copy number of mitochondria in the oocyte cell.

Methods

This covered the researches from 1966 to September 2015.

Results

The results provided ten methods that can be studied individually or simultaneously.

Conclusion

Though the use of these techniques generated great concern about heteroplasmy observation in humans, it seems that with study on these suggested methods there is real hope for effective treatments of old oocyte or oocytes containing mitochondrial problems in the near future.