TLR4 is involved in the physiological and pathological progress of DM and AD respectively.
10">In DM, chronic TLR4 activation may contribute to the insulin resistance.
15">In AD, chronic long-term TLR4 activation may lead to Aβ deposition.
TLR4 as a potential link between DM and AD is reviewed.
TLR4 as a link of between DM and AD further explain the theory that AD is regarded as types 3 diabetes.