Pre-Transplantation Immune Cell Distribution and Early Post-Transplant Fungal Infection Are the Main Risk Factors of Liver Transplantation Recipients in Lower Model of End-Stage Liver Disease

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• 作者：N.M. Abdelhamid^a ; ^c ; Y.-C. Chen^b ; ^c ; Y.-C. Wang^c ; C.-H. Cheng^c ; T.-J. Wu^c ; C.-F. Lee^c ; T.-H. Wu^c ; H.-S. Chou^c ; K.-M. Chan^c ; W.-C. Lee^c ; ^d ; R.-S. Soong^b ; ^c ; ^d ; ^{kodlp62@gmail.com}
• 刊名：Transplantation Proceedings
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：49
• 期：1
• 页码：92-97
• 全文大小：702 K
• 卷排序：49

文摘

The prognosis of patients after liver transplantation (LTx) with high Model of End-Stage Liver Disease (MELD) score (>30) is predicted, but patients with lower MELD scores (<30) have no conclusive studies of pre- and post-transplant risk factors that influence the long-term outcome.MethodsThis retrospective study reviewed 268 recipients with MELD score <30, from 2008 to 2013 in our institution, for evaluation of pre-transplant risk factors including patients' clinical background data, pre-transplant lymphocyte subpopulation, and early post-transplant infection complication as predictors for long-term survival after LTx.ResultsThe post-transplant patients' survival estimates were 90.7%, 85.1%, and 83.6% at 1, 3, and 5 years, respectively. In multivariate analysis, age >55years, presence of ascites, cluster of differentiation (CD)3 < 93.2 (count/μL), CD4/CD8 <2.4, fungal infection, and more than one site of fungal colonization significantly influenced survival (P = .0003, P = .002, P = .04, P = .004, P < .0001, and P > .0001, respectively). We also noticed that these five factors accumulatively influence the long-term survival rate; this means that in the presence of any two risk factors, the 5-year survival can still be 88.4%, whereas in the presence of any three risk factors, the survival rate dropped to only 57.1%.ConclusionsOlder patients in the presence of pre-transplant low immune cell number and ascites in association with post-transplant fungal infection are the independent risk factors in MELD scores <30 LTx groups for long-term survival. Patients in these groups with any of the three factors had inferior long-term survival results.