Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression

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• 作者：Hidemasa Torii^a ; ^b ; Toshihide Kurihara^a ; ^b ; Yuko Seko^c ; Kazuno Negishi^a ; Kazuhiko Ohnuma^d ; Takaaki Inaba^a ; ^e ; Motoko Kawashima^a ; Xiaoyan Jiang^a ; ^b ; Shinichiro Kondo^a ; Maki Miyauchi^a ; ^b ; Yukihiro Miwa^a ; ^b ; Yusaku Katada^a ; ^b ; Kiwako Mori^a ; ^b ; Keiichi Kato^f ; Kinya Tsubota^b ; ^g ; Hiroshi Goto^g ; Mayumi Oda^h ; Megumi Hatori^a ; ^b ; ⁱ ; Kazuo Tsubota^a ; ^{tsubota@z3.keio.jp}
• 关键词：Violet light ; Ultraviolet light ; Outdoors ; Myopia ; Axial length ; Refraction
• 刊名：EBioMedicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：15
• 期：Complete
• 页码：210-219
• 全文大小：1480 K
• 卷排序：15

文摘

Violet light (360–400 nm wavelengths) suppressed the axial length elongation both in a chick myopia model and in human. The myopia suppressive gene EGR1 was upregulated by the violet light exposure. Violet light, one of the myopia suppressive factors in the outdoor environment, is deficient from our modern society.Short-sightedness (myopia) has been increasing worldwide especially over the past 50 years. Our studies on chicks and humans revealed that violet light (360–400 nm wavelength) suppressed myopia progression. At a molecular level we found that violet light increased the expression of the gene EGR1 known to prevent myopia. Interestingly, violet light is deficient in our modern society because various ultraviolet-protected products are not transmitting violet light, and light sources such as LED irradiate no violet light. Ultraviolet protection is important for ocular health, but excessive ultraviolet protection, including violet light, should be reconsidered from the aspect of myopia control.