Structural Basis for Translation Termination on a Pseudouridylated Stop Codon
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- 作者：Egor Svidritskiy ; Rohini Madireddy ; Andrei A. Korostelev ; andrei.korostelev@umassmed.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：pseudouridine ; post-transcriptional modification of mRNA ; translation regulation ; stop-codon read through ; translation termination
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：22 May 2016
- 年：2016
- 卷：428
- 期：10
- 页码：2228-2236
- 全文大小：1119 K
文摘
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Structural recognition of the ΨAA stop codon by RF1 is identical to that of the UAA codon.
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Biochemical experiments show that RF1 and RF2 do not distinguish between pseudouridylated and canonical stop codons.
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The tail of L27 in the peptidyl-transferase center rearranges upon RF1 binding.