Deoxynivalenol induces apoptosis in PC12 cells via the mitochondrial pathway
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- 作者：Xichun Wang<sup>1sup><sup> ; sup><sup>wangxichun@ahau.edu.cn" class="auth_mail" title="E-mail the corresponding authorsup> ; Wei Xu<sup>1sup><sup> ; sup><sup>xwdd136@163.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Mengxue Fan<sup>1sup><sup> ; sup><sup>1464981421@qq.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Tingting Meng <sup>649449698@qq.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Xiaofang Chen <sup>912012949@qq.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Yunjing Jiang <sup>597913559@qq.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Dianfeng Zhu <sup>1473007481@qq.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Wenjuan Hu <sup>1299791970@qq.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Jiajie Gong <sup>798500733@qq.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Shibin Feng <sup>luyifsb@126.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Jinjie Wu<sup> ; sup><sup>wjj@ahau.edu.cn" class="auth_mail" title="E-mail the corresponding authorsup> ; Yu Li<sup> ; sup><sup>lydhy2014@ahau.edu.cn" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：DON ; deoxynivalenol ; Cyt C ; cytochrome C ; AIF ; apoptosis inducing factor ; DMEM ; dulbecco&rsquo ; s modified eagle&rsquo ; s medium ; FBS ; fetal bovine serum ; CCK-8 ; cell counting kit-8 ; OD ; optical density ; BSA ; bovine serum albumin ; PI ; propidium iodide ; LDH ; lactate dehydrogenase ; PVDF ; polyvinylidene fluoride membranes ; RT-PCR ; real-time polymerase chain reaction ; SD ; standard deviation ; ANOVA ; analysis of variance ; TBST ; tris-buffered saline and tween-20
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：43
- 期：Complete
- 页码：193-202
- 全文大小：3647 K
文摘
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DON induces PC12 cell apoptosis via mitochondrial apoptosis pathway.
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DON inhibits Bcl-2 expression and promotes expression of Bax and Bid.
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DON promotes activation of mediators of mitochondrial apoptosis.
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The Caspase8 inhibitor (FMK) opposes DON activity on mitochondrial apoptosis.