MicroRNA-146a down-regulation correlates with neuroprotection and targets pro-apoptotic genes in cerebral ischemic injury in vitro
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- 作者：Xia Zhou<sup>asup><sup> ; sup><sup>1sup> ; Shengyou Su<sup>asup><sup> ; sup><sup>1sup> ; Shenghua Li<sup>asup> ; Xiaomin Pang<sup>bsup> ; Chunyong Chen<sup>asup> ; Jinpin Li<sup>asup> ; Jingli Liu<sup>asup><sup> ; sup><sup>lilicomet@163.com" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：miRNA ; microRNA ; OGD/R ; oxygen-glucose deprivation and reperfusion ; Bclaf1 ; Bcl-2-associated factor 1 ; qRT-PCR ; quantitative real-time polymerase chain reaction ; 3&prime ; -UTR ; 3&prime ; -untranslated region ; MCAO ; middle cerebral artery occlusion ; I/R ; ischemia/reperfusion ; DMEM ; Dulbecco's modified Eagle's medium ; FBS ; fetal bovine serum
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：1648
- 期：part_PA
- 页码：136-143
- 全文大小：3828 K
文摘
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MiR-146a was decreased in oxygen-glucose deprivation and reperfusion injury in vitro.
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MiR-146a regulated the expression of Caspase7 and Bclaf1.
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MiR-146a increased cell apoptosis while decreased the expression of pro-apoptosis protein, Caspase7 and Bclaf1.