Oxyresveratrol abrogates oxidative stress by activating ERK-Nrf2 pathway in the liver
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- 作者：Hee Yoon Choi<sup>asup><sup> ; sup><sup>1sup> ; Ju-Hee Lee<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>1sup> ; Kyung Hwan Jegal<sup>asup> ; Il Je Cho<sup>asup> ; Young Woo Kim<sup>asup><sup> ; sup><sup>ywkim@dhu.ac.kr" class="auth_mail" title="E-mail the corresponding authorsup> ; Sang Chan Kim<sup>asup><sup> ; sup><sup>sckim@dhu.ac.kr" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：ARE ; antioxidant response element ; DCFH-DA ; 2&prime ; 7&prime ; -dichlorofluorescin diacetate ; DMEM ; Dulbecco&rsquo ; s modified Eagle&rsquo ; s medium ; DMSO ; dimethyl sulfoxide ; DTT ; 1 ; 4-dithiothretiol ; ERK ; extracellular signal-regulated kinases ; FBS ; fetal bovine serum ; GCLC ; glutamate&ndash ; cystein ligase catalytic subunit ; GSH ; glutathione ; GSTA2 ; glutathione S-transferase A2 ; HO-1 ; heme oxygenase-1 ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-dipheny-tetrazolium bromide ; Nrf2 ; NF-E2 related factor 2 ; O
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：5 February 2016
- 年：2016
- 卷：245
- 期：Complete
- 页码：110-121
- 全文大小：2533 K
文摘
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Oxyresveratrol protected hepatocytes against oxidative stress, mitochondrial damage, and resultant cell death.
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Oxyresveratrol also ameliorated acute liver injury caused by CCl<sub>4sub> in mice.
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Oxyresveratrol induced activation of an antioxidant transcription factor, Nrf2, mediated through ERK phosphorylation.
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These events may have a role in its protective effects in the liver.