Applicability of modified Glasgow Prognostic Score in the assessment of elderly patients with cancer: A pilot study

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• 作者：Viviane Lealdini^a ; Damila Cristina Trufelli^b ; ^{damilatrufelli@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author} ; Fernanda Borges Ferreira da Silva^a ; Savia Raquel Costa Normando^a ; Elisa Watanabe Camargo^a ; Leandro Luongo de Matos^c ; Fernando Luiz Affonso Fonseca^d ; Patricia Xavier Santi^b ; Auro Del Giglio^a
• 关键词：Neoplasia ; Prognosis ; Elderly
• 刊名：Journal of Geriatric Oncology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：6
• 期：6
• 页码：479-483
• 全文大小：325 K

文摘

To evaluate the relationship between inflammatory parameters through the modified Glasgow Prognostic Score (mGPS) and other clinical characteristics of elderly patients with cancer, including frailty evaluated by the Edmonton Frailty Scale (EFS).

Materials and Methods

We included patients from the oncology service at Faculdade de Medicina do ABC with a confirmed diagnosis of solid tumor aged 65 years or more at diagnosis. Patients were assessed by applying the translated and validated to Portuguese version of the EFS and also had blood sample collection for the evaluation of C-reactive protein (CRP) and albumin for calculation of the mGPS.

Results

We included 52 patients of both sexes, with median age of 72.5 years, of these 67.3% had localized disease and 32.7% metastatic disease. The mGPS presented 17.3% of high-risk patients. The frailty evaluated by EFS occurred in 57.6% of patients. Patients with both abnormal parameters (CRP and albumin) in the mGPS had significantly higher scores on EFS when compared to those with no change (6 vs. 9.56 points, p = 0.021). The mGPS correlated also with clinical staging (p = 0.019) and performance status (p = 0.039).

Conclusions

Inflammatory parameters correlate significantly with frailty, more advanced clinical stage and poor functional status.