Huperzine A: A promising anticonvulsant, disease modifying, and memory enhancing treatment option in Alzheimer’s disease

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• 作者：Ugur Damar^a ; Roman Gersner^a ; Joshua T. Johnstone^b ; Steven Schachter^c ; Alexander Rotenberg^a ; ^{Alexander.Rotenberg@childrens.harvard.edu}
• 关键词：Huperzine A ; Acetylcholinesterase ; Nicotinic ; Seizure ; Alzheimer&rsquo ; s disease ; Antiepileptic ; ppTMS
• 刊名：Medical Hypotheses
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：99
• 期：Complete
• 页码：57-62
• 全文大小：564 K
• 卷排序：99

文摘

Alzheimer’s disease is a risk factor for epilepsy. Conventional antiepileptic drugs may exacerbate cognitive disability in AD. HupA is a safe AChE inhibitor with antiepileptic potential in preclinical studies. HupA has acute anti-seizure activity via increasing GABAergic signaling. HupA may improve cortical excitation:inhibition ratio by modulating TNF-α and IL-1β. Therapeutic HupA effects in AD may include mediating Aβ deposition, NPY-NGF cells and NL1.